| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T17448 | ||||
| Target Name | Histamine N-methyltransferase (HNMT) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Amodiaquine | Drug Info | IC50 = 0.50 microM | [2] | |
| Action against Disease Model | Amodiaquine | Drug Info | IC50 for Plasmodi uM falcipar uM isolates from Kericho, Kenya: 3 ng/mL | [1] | |
| References | |||||
| REF 1 | Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya. Antimicrob Agents Chemother. 2004 Sep;48(9):3598-601. | ||||
| REF 2 | Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. Mol Pharmacol. 1994 Mar;45(3):461-8. | ||||
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