Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T22769 | ||||
Target Name | Telomerase protein component 1 (TEP1) | ||||
Type of Target |
Literature-reported |
||||
Drug Potency against Target | Imetelstat | Drug Info | IC50 = 3~300 nM | [1] | |
Action against Disease Model | Imetelstat | Drug Info | Extracts from HME50-5E cells lysed with NP-40 lysis buffer were incubated with 0.001-100 nM GRN163 or GRN163L for 30 min and then processed for telomerase activity assays. The IC50 values were approx1.4 and approx7.8 nM for GRN163 and GRN163L, respectively. | ||
References | |||||
REF 1 | Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1577-9. | ||||
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