Target Validation Information
TTD ID T22769
Target Name Telomerase protein component 1 (TEP1)
Type of Target
Literature-reported
Drug Potency against Target Imetelstat Drug Info IC50 = 3~300 nM [1]
Action against Disease Model Imetelstat Drug Info Extracts from HME50-5E cells lysed with NP-40 lysis buffer were incubated with 0.001-100 nM GRN163 or GRN163L for 30 min and then processed for telomerase activity assays. The IC50 values were approx1.4 and approx7.8 nM for GRN163 and GRN163L, respectively.
References
REF 1 Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1577-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.