Target Validation Information
TTD ID	T22839
Target Name	Pancreatic elastase 1 (CELA1)
Type of Target	Successful
Drug Potency against Target	Acetyl-Ala-Ala-Pro-Ala-trifluromethane	Drug Info	Ki = 150 nM	[3]
	Acetyl-Pro-Ala-Pro-Ala-trifluoro methane	Drug Info	Ki = 240 nM	[3]
	Grassystatin a	Drug Info	IC50 = 10000 nM	[1]
	MOLASSAMIDE	Drug Info	IC50 = 32 nM	[2]
References
REF 1	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
REF 2	Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. J Nat Prod. 2010 Mar 26;73(3):459-62.
REF 3	Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, ... J Med Chem. 1990 Jan;33(1):394-407.

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