| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T23471 | ||||
| Target Name | Myeloperoxidase (MPO) | ||||
| Type of Target |
Clinical trial |
||||
| Action against Disease Model | 4-aminobenzoic acid hydrazide | Drug Info | Pretreatment of MPO-high leukemia cells with a MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, or a MPO-specific small interfering RNA (siRNA) abrogated the PTL-induced ROS generation and apoptosis, indicating that MPO plays a crucial role in PTL-induced apoptosis in leukemia cells. | [1] | |
| References | |||||
| REF 1 | Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther. 2010 Nov;335(2):389-400. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.