Target Validation Information
TTD ID	T24587
Target Name	O-6-methylguanine-DNA-alkyltransferase (MGMT)
Type of Target	Clinical trial
Drug Potency against Target	6-Allyloxy-9H-purin-2-ylamine	Drug Info	IC50 = 5100 nM	[1]
	6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine	Drug Info	IC50 = 1300 nM	[2]
	6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine	Drug Info	IC50 = 130 nM	[2]
	6-Benzyloxy-9H-purin-2-ylamine	Drug Info	IC50 = 2600 nM	[2]
References
REF 1	Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83.
REF 2	Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.