| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T25136 | ||||
| Target Name | Human immunodeficiency virus Ribonuclease H (HIV RNH) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 2-hydroxyisoquinoline-1,3(2H,4H)-dione | Drug Info | IC50 = 120 nM | [1] | |
| 3-hydroxyquinazoline-2,4(1H,3H)-dione | Drug Info | IC50 = 5900 nM | [1] | ||
| References | |||||
| REF 1 | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem. 2009 Oct 8;52(19):5781-4. | ||||
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