| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T27265 | ||||
| Target Name | Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Dutasteride | Drug Info | Ki = 4.3 nM | [2] | |
| Finasteride | Drug Info | Ki = 23 nM | [2] | ||
| Dutasteride + tamsulosin | Drug Info | IC50 = 6 nM | [1] | ||
| References | |||||
| REF 1 | Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004 Feb 1;58(2):130-44. | ||||
| REF 2 | Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride. J Mol Endocrinol. 2005 Jun;34(3):617-23. | ||||
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