Target Validation Information
TTD ID	T30823
Target Name	M-phase inducer phosphatase 1 (MPIP1)
Type of Target	Literature-reported
Drug Potency against Target	(E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid	Drug Info	IC50 = 13000 nM	[2]
	(Z)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid	Drug Info	IC50 = 12000 nM	[2]
	1-dodecyl-1H-indole-2,3-dione	Drug Info	IC50 = 15000 nM	[2]
	2-(1-dodecyl-1H-indol-3-yl)acetic acid	Drug Info	IC50 = 8000 nM	[2]
	3-isopropyl-4-(phenylamino)naphthalene-1,2-dione	Drug Info	IC50 = 10880 nM	[1]
	3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	Drug Info	IC50 = 5860 nM	[1]
	3-isopropyl-4-phenylnaphthalene-1,2-dione	Drug Info	IC50 = 7830 nM	[1]
	3-isopropylnaphthalene-1,2-dione	Drug Info	IC50 = 11180 nM	[1]
	4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	Drug Info	IC50 = 7060 nM	[1]
	NSC-95397	Drug Info	IC50 = 5500 nM	[3]
References
REF 1	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
REF 2	Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3.
REF 3	Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4.

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