Target Validation Information
TTD ID	T31479
Target Name	Phospholipase A2 (PLA2G1B)
Type of Target	Successful
Drug Potency against Target	Mepacrine	Drug Info	IC50 = 17 uM
	3,9-dihydroxy-2,10-diprenylpterocap-6a-ene	Drug Info	IC50 = 3000 nM
	4'-hydroxy-6,3',5'-triprenylisoflavonone	Drug Info	IC50 = 10000 nM
	ABYSSINONE V	Drug Info	IC50 = 6000 nM
	BOLINAQUINONE	Drug Info	IC50 = 100 nM	[1]
	CACOSPONGIONOLIDE	Drug Info	IC50 = 2300 nM	[6]
	HELENAQUINONE	Drug Info	IC50 = 3700 nM	[4]
	Hyrtiosulawesine	Drug Info	IC50 = 14000 nM	[3]
	MANOALIDE	Drug Info	IC50 = 400 nM	[3]
	Petrosaspongiolide P	Drug Info	IC50 = 3800 nM	[5]
	URSOLIC ACID	Drug Info	IC50 = 2300 nM	[2]
References
REF 1	New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.
REF 2	Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.
REF 3	Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus. J Nat Prod. 2006 Dec;69(12):1676-9.
REF 4	New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg Med Chem. 2010 Aug 15;18(16):6006-11.
REF 5	Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. J Nat Prod. 1998 May;61(5):571-5.
REF 6	A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.

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