| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T33966 | ||||
| Target Name | Carboxypeptidase A1 (CPA1) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | DL-benzylsuccinic acid | Drug Info | Ki = 500 nM | [2] | |
| SQ-14603 | Drug Info | Ki = 11 nM | [1] | ||
| References | |||||
| REF 1 | Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem. 2007 Nov 29;50(24):6095-103. | ||||
| REF 2 | A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. | ||||
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