Target Validation Information
TTD ID T35194
Target Name Dual specificity protein phosphatase 1 (DUSP1)
Type of Target
Clinical trial
Drug Potency against Target 4-ethoxynaphthalene-1,2-dione Drug Info IC50 = 820 nM [1]
ADOCIAQUINONE B Drug Info IC50 = 1100 nM [1]
Avastin+/-Tarceva Drug Info IC50 = 13000 nM [1]
References
REF 1 Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.

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