Target Validation Information
TTD ID	T37847
Target Name	Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Type of Target	Successful
Drug Potency against Target	(+)-Myristinin A	Drug Info	Ki = 11000 nM	[5]
	(+)-Myristinin D	Drug Info	Ki = 12000 nM	[5]
	(24E)-3beta-hydroxy-7,24-euphadien-26-oic acid	Drug Info	Ki = 2800 nM	[3]
	3-Oximo-olean-12-en-29-oic acid	Drug Info	IC50 = 16000 nM	[2]
	3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid	Drug Info	IC50 = 2900 nM	[1]
	6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione	Drug Info	Ki = 18600 nM	[9]
	6-(4-Bromo-phenylamino)-1H-pyrimidine-2,4-dione	Drug Info	Ki = 4000 nM	[9]
	6-(4-Chloro-phenylamino)-1H-pyrimidine-2,4-dione	Drug Info	Ki = 14100 nM	[9]
	Alpha,beta-methylene-dATP	Drug Info	Ki = 5000 nM	[7]
	Alpha,beta-methylene-dCTP	Drug Info	Ki = 900 nM	[7]
	Alpha,beta-methylene-dGTP	Drug Info	Ki = 1000 nM	[7]
	Alpha,beta-methylene-dTTP	Drug Info	Ki = 600 nM	[7]
	DdCTP SODIUM	Drug Info	IC50 = 1300 nM	[4]
	Gallic acid 5,6-dihydroxy-3-carboxyphenylester	Drug Info	Ki = 390 nM
	Mahureone D	Drug Info	IC50 = 12000 nM	[4]
	PENICILLIOL A	Drug Info	IC50 = 19800 nM	[8]
	TALAROFLAVONE	Drug Info	IC50 = 16300 nM	[6]
References
REF 1	Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata. J Nat Prod. 1999 Jul;62(7):1000-2.
REF 2	DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod. 1999 Aug;62(8):1110-3.
REF 3	A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta. J Nat Prod. 2000 Oct;63(10):1356-60.
REF 4	Acylphloroglucinol derivatives from Mahurea palustris. J Nat Prod. 2005 Jul;68(7):979-84.
REF 5	(+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA. J Nat Prod. 2005 Nov;68(11):1625-8.
REF 6	1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae. Bioorg Med Chem. 2008 Mar 15;16(6):2939-44.
REF 7	Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70.
REF 8	Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorg Med Chem. 2009 Mar 1;17(5):1811-6.
REF 9	Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.