Target Validation Information
TTD ID	T38529
Target Name	Prostaglandin E2 receptor EP2 (PTGER2)
Type of Target	Successful
Drug Potency against Target	Iloprost	Drug Info	IC50 = 12.6 nM	[4]
	3-(2-((E)-3-phenylprop-1-enyl)phenyl)acrylic acid	Drug Info	Ki = 1400 nM	[1]
	3-(2-(4-methoxycinnamyl)phenyl)acrylic acid	Drug Info	Ki = 2500 nM	[1]
	3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid	Drug Info	Ki = 12000 nM	[1]
	3-(2-cinnamylphenyl)acrylic acid	Drug Info	Ki = 1400 nM	[1]
	BUTAPROST	Drug Info	Ki = 110 nM	[3]
	LAROPIPRANT	Drug Info	Ki = 136 nM	[2]
References
REF 1	Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42.
REF 2	Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806.
REF 3	Synthesis and evaluation of a gamma-lactam as a highly selective EP2 and EP4 receptor agonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):821-4.
REF 4	Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. Br J Pharmacol. 1992 Apr;105(4):817-24.

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