| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T38875 | ||||
| Target Name | AMP-activated protein kinase (AMPK) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol | Drug Info | IC50 = 7700 nM | [2] | |
| Dorsomorphin | Drug Info | IC50 = 41 nM | [2] | ||
| SU 6656 | Drug Info | IC50 = 110 nM | [1] | ||
| References | |||||
| REF 1 | The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. | ||||
| REF 2 | The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular a... Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. | ||||
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