| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T38996 | ||||
| Target Name | Phospholipase D1 (PLD1) | ||||
| Type of Target |
Patented-recorded |
||||
| Drug Potency against Target | 1-(pyridin-2-yl)piperazine | Drug Info | IC50 = 3600 nM | [2] | |
| 1-(pyridin-4-yl)piperazine | Drug Info | IC50 = 3600 nM | [2] | ||
| Afimoxifene | Drug Info | IC50 = 4800 nM | [1] | ||
| HALOPEMIDE | Drug Info | IC50 = 21 nM | [1] | ||
| References | |||||
| REF 1 | Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. | ||||
| REF 2 | Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privil... Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.