| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T40149 | ||||
| Target Name | PKC-eta messenger RNA (PRKCH mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 8-Octyl-benzolactam-V9 | Drug Info | Ki = 144 nM | [2] | |
| BALANOL | Drug Info | IC50 = 20 nM | |||
| LY-326449 | Drug Info | IC50 = 300 nM | [3] | ||
| PROSTRATIN | Drug Info | Ki = 190 nM | [1] | ||
| References | |||||
| REF 1 | A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. | ||||
| REF 2 | Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. | ||||
| REF 3 | (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. | ||||
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