| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T40332 | ||||
| Target Name | Neutrophil elastase (NE) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Sivelestat sodium hydrate | Drug Info | IC50 = 44 nM | [11] | |
| (1H-pyrazol-1-yl)(o-tolyl)methanone | Drug Info | Ki = 3400 nM | [4] | ||
| (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone | Drug Info | Ki = 104 nM | [4] | ||
| (3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone | Drug Info | Ki = 28 nM | [4] | ||
| (3-nitro-1H-pyrazol-1-yl)(phenyl)methanone | Drug Info | Ki = 46 nM | [4] | ||
| (4-bromo-1H-pyrazol-1-yl)(m-tolyl)methanone | Drug Info | Ki = 250 nM | [4] | ||
| (4-bromo-1H-pyrazol-1-yl)(o-tolyl)methanone | Drug Info | Ki = 300 nM | [4] | ||
| (4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone | Drug Info | Ki = 45 nM | [4] | ||
| (4-chloro-1H-pyrazol-1-yl)(o-tolyl)methanone | Drug Info | Ki = 230 nM | [4] | ||
| (4-nitro-1H-pyrazol-1-yl)(o-tolyl)methanone | Drug Info | Ki = 65 nM | [4] | ||
| (4-nitro-1H-pyrazol-1-yl)(phenyl)methanone | Drug Info | Ki = 34 nM | [4] | ||
| 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide | Drug Info | Ki = 39 nM | [4] | ||
| 1-benzyl-3,3-diethylazetidine-2,4-dione | Drug Info | Ki = 114 nM | [8] | ||
| 1-benzyl-3,3-dimethylazetidine-2,4-dione | Drug Info | Ki = 34.4 nM | [8] | ||
| 2-methylbut-3-yn-2-yl 4-methoxybenzoate | Drug Info | Ki = 110 nM | [4] | ||
| 3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione | Drug Info | Ki = 2.2 nM | [8] | ||
| 3,3-Diethyl-1-o-tolylazetidine-2,4-dione | Drug Info | Ki = 233 nM | [8] | ||
| 3,3-diethyl-1-phenylazetidine-2,4-dione | Drug Info | Ki = 1.21 nM | [8] | ||
| 3,4-dichloroisocoumarin | Drug Info | IC50 = 3000 nM | [1] | ||
| 3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione | Drug Info | Ki = 127 nM | [8] | ||
| 3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione | Drug Info | Ki = 4450 nM | [8] | ||
| 3-butyl-3-ethyl-1-phenylazetidine-2,4-dione | Drug Info | Ki = 0.85 nM | [8] | ||
| 3-Decanoyl-4-hydroxy-6-nonyl-pyran-2-one | Drug Info | Ki = 7900 nM | [10] | ||
| 3-Ethyl-3-isobutyl-1-phenylazetidine-2,4-dione | Drug Info | Ki = 3.9 nM | [8] | ||
| 4-Hydroxy-3-nonanoyl-6-octyl-pyran-2-one | Drug Info | Ki = 4600 nM | [10] | ||
| 4-methoxy-N'-(2-phenylacetyl)benzohydrazide | Drug Info | Ki = 2500 nM | [4] | ||
| 6-Heptyl-4-hydroxy-3-octanoyl-pyran-2-one | Drug Info | Ki = 15000 nM | [10] | ||
| Ac-Ala-Pro-Val-(2-benzoxazole) | Drug Info | Ki = 73 nM | [5] | ||
| Bornyl (3,4,5-trihydroxy)-cinnamate | Drug Info | IC50 = 540 nM | [6] | ||
| Cbz-Val-Pro-Val-(2-benzoxazole) | Drug Info | Ki = 3 nM | [5] | ||
| Delanzomib | Drug Info | IC50 = 3550 nM | [7] | ||
| E-6-O-p-methoxycinnamoyl scandoside methyl ester | Drug Info | IC50 = 18000 nM | [9] | ||
| Epigallocatechin gallate | Drug Info | IC50 = 12800 nM | [9] | ||
| FR-901277 | Drug Info | Ki = 12 nM | [2] | ||
| FR-901451 | Drug Info | Ki = 10 nM | [2] | ||
| N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide | Drug Info | Ki = 290 nM | [4] | ||
| WIN-63395 | Drug Info | Ki = 0.27 nM | |||
| ZK-814048 | Drug Info | Ki = 10000 nM | [3] | ||
| References | |||||
| REF 1 | Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and G... Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. | ||||
| REF 2 | Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor sc... Bioorg Med Chem. 2007 Jul 1;15(13):4618-28. | ||||
| REF 3 | Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. | ||||
| REF 4 | N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. | ||||
| REF 5 | Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. | ||||
| REF 6 | Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations. Bioorg Med Chem. 2008 Mar 1;16(5):2385-90. | ||||
| REF 7 | Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem. 2008 Feb 28;51(4):1068-72. | ||||
| REF 8 | 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. | ||||
| REF 9 | Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett. 2010 Jan 15;20(2):513-5. | ||||
| REF 10 | Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem. 1987 Jun;30(6):1017-23. | ||||
| REF 11 | Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. Inflamm Res. 2009 Apr;58(4):198-203. | ||||
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