| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T40696 | ||||
| Target Name | Staphylococcus Topoisomerase IV (Stap-coc parC) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Gatifloxacin | Drug Info | IC50 = 13800 ng/mL | [1] | |
| Sparfloxacin | Drug Info | IC50 = 19100 ng/mL | [2] | ||
| References | |||||
| REF 1 | Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81. | ||||
| REF 2 | Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV of Enterococcus faecalis. Antimicrob Agents Chemother. 2002 Jun;46(6):1800-4. | ||||
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