| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T41515 | ||||
| Target Name | FGFR4 messenger RNA (FGFR4 mRNA) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | PD-0183812 | Drug Info | IC50 = 8620 nM | [1] | |
| Ro-4396686 | Drug Info | IC50 = 92 nM | [2] | ||
| References | |||||
| REF 1 | Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. | ||||
| REF 2 | Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. | ||||
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