| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T42000 | ||||
| Target Name | Interleukin-1 beta (IL1B) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Gallium nitrate | Drug Info | IC50 = 10 nM | [2] | |
| Glucosamine | Drug Info | IC50 = 25 mg/ml | [1] | ||
| References | |||||
| REF 1 | Effect of glucosamine on interleukin-1-conditioned articular cartilage. Equine Vet J Suppl. 2002 Sep;(34):219-23. | ||||
| REF 2 | Gallium nitrate inhibits bone resorption and collagen synthesis in neonatal mouse calvariae. J Bone Miner Res. 1991 Oct;6(10):1121-6. | ||||
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