Target Validation Information
TTD ID	T45299
Target Name	Tissue-type plasminogen activator (PLAT)
Type of Target	Successful
Drug Potency against Target	1-guanidino-N-phenyl-7-isoquinolinesulphonamide	Drug Info	Ki = 15000 nM	[3]
	2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine	Drug Info	Ki = 9400 nM	[1]
	BMS-344577	Drug Info	Ki = 665 nM	[4]
	N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine	Drug Info	Ki = 19000 nM	[2]
	N-(5-Benzyloxy-isoquinolin-1-yl)-guanidine	Drug Info	Ki = 13000 nM	[2]
	N-(7-Benzyloxy-isoquinolin-1-yl)-guanidine	Drug Info	Ki = 13000 nM	[2]
References
REF 1	Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71.
REF 2	Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30.
REF 3	Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.
REF 4	Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.