Target Validation Information
TTD ID	T46365
Target Name	M-phase inducer phosphatase 2 (MPIP2)
Type of Target	Clinical trial
Drug Potency against Target	3-isopropyl-4-(phenylamino)naphthalene-1,2-dione	Drug Info	IC50 = 8710 nM	[1]
	3-isopropyl-4-(phenylthio)naphthalene-1,2-dione	Drug Info	IC50 = 10860 nM	[1]
	3-isopropyl-4-phenylnaphthalene-1,2-dione	Drug Info	IC50 = 3230 nM	[1]
	4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione	Drug Info	IC50 = 4530 nM	[1]
	4-ethoxynaphthalene-1,2-dione	Drug Info	IC50 = 270 nM	[3]
	5,6,7,8-tetrahydroanthracene-1,4-dione	Drug Info	IC50 = 9530 nM	[3]
	6,7-dibromoquinoline-5,8-dione	Drug Info	IC50 = 5300 nM	[2]
	ADOCIAQUINONE B	Drug Info	IC50 = 70 nM	[2]
	ANTHRAQUINONE	Drug Info	IC50 = 9510 nM	[3]
	Avastin+/-Tarceva	Drug Info	IC50 = 1980 nM	[3]
	NSC-95397	Drug Info	IC50 = 3770 nM	[2]
References
REF 1	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
REF 2	Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
REF 3	Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.

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