| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T46700 | ||||
| Target Name | Cot oncogene messenger RNA (MAP3K8 mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 8-chloro-quinoline-3-carbonitrile | Drug Info | IC50 = 12 nM | [1] | |
| References | |||||
| REF 1 | Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304. | ||||
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