| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T47941 | ||||
| Target Name | Phosphodiesterase 4 (PDE4) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Arofylline | Drug Info | IC50 = 5500 nM | [1] | |
| Cilomilast | Drug Info | IC50 = 120 nM | |||
| Action against Disease Model | Cilomilast | Drug Info | Cilomilast has an IC50 value of 30 nM against PDE4 from U937 cells and inhibits the LPS-induced TNF-a release in whole blood with an IC50 of 7.3 uM. | [2] | |
| References | |||||
| REF 1 | Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies. Eur J Med Chem. 2000 May;35(5):463-80. | ||||
| REF 2 | The next generation of PDE4 inhibitors. Curr Opin Chem Biol. 2001 Aug;5(4):432-8. | ||||
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