| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T48330 | ||||
| Target Name | Large neutral amino acids transporter 1 (SLC7A5) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | (+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid | Drug Info | Ki = 7700 nM | [1] | |
| (+/-)-2-Aminoindane-2-carboxylic acid | Drug Info | Ki = 12500 nM | [1] | ||
| References | |||||
| REF 1 | Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. | ||||
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