| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T49995 | ||||
| Target Name | Arylamine N-acetyltransferase (NAT) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | (Z)-5-Benzylidene-2-thioxothiazolidin-4-one | Drug Info | IC50 = 13000 nM | [1] | |
| (Z)-5-Butylidene-2-thioxothiazolidin-4-one | Drug Info | IC50 = 7700 nM | [1] | ||
| (Z)-5-Decylidene-2-thioxothiazolidin-4-one | Drug Info | IC50 = 10200 nM | [1] | ||
| (Z)-5-Hexylidene-2-thioxothiazolidin-4-one | Drug Info | IC50 = 1300 nM | [1] | ||
| (Z)-5-Octylidene-2-thioxothiazolidin-4-one | Drug Info | IC50 = 6800 nM | [1] | ||
| References | |||||
| REF 1 | Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. | ||||
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