| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T52173 | ||||
| Target Name | Amiloride-sensitive sodium channel (ENaC) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Amiloride | Drug Info | IC50 = 10~C50 mM | [2] | |
| Triamterene | Drug Info | IC50 = 4500 nM | [1] | ||
| References | |||||
| REF 1 | Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol Pharmacol. 2003 Oct;64(4):848-56. | ||||
| REF 2 | Non-selective cation channel blockers: potential use in nervous system basic research and therapeutics. Mini Rev Med Chem. 2008 Jul;8(8):812-9. | ||||
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