Target Validation Information
TTD ID	T52227
Target Name	Candida Thymidylate synthase (Candi TMP1)
Type of Target	Successful
Drug Potency against Target	Fluorouracil	Drug Info	IC50 = 899 nM	[6]
		Drug Info	IC50 = 100 nM	[1]
		Drug Info	IC50 = 19 nM	[3]
	1,3-propanediphosphonic acid	Drug Info	Ki = 2700 nM	[4]
	3-Amino-5,6-dihydro-2H-benzo[f]quinazolin-1-one	Drug Info	Ki = 7000 nM	[5]
	3-Methyl-2H-benzo[f]quinazolin-1-one	Drug Info	Ki = 5400 nM	[5]
	PREMETREXED	Drug Info	IC50 = 9500 nM	[2]
References
REF 1	Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methy... J Med Chem. 2005 Nov 17;48(23):7215-22.
REF 2	Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical ... J Med Chem. 2006 Feb 9;49(3):1055-65.
REF 3	Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual th... J Med Chem. 2009 Aug 13;52(15):4892-902.
REF 4	Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J Med Chem. 2010 Sep 23;53(18):6539-49.
REF 5	Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related de... J Med Chem. 1993 Oct 29;36(22):3464-71.
REF 6	Mechanism of action of key enzymes associated with cancer propagation and their inhibition by various chemotherapeutic agents. Mini Rev Med Chem. 2008 Apr;8(4):388-98.

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