Target Validation Information
TTD ID	T53748
Target Name	Plasmodium Enoyl-ACP reductase (Malaria fabI)
Type of Target	Successful
Drug Potency against Target	Triclosan	Drug Info	IC50 = 100 nM	[7]
	(-)-CATECHINGALLATE	Drug Info	Ki = 40 nM	[2]
	2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol	Drug Info	IC50 = 290 nM	[6]
	2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol	Drug Info	IC50 = 440 nM	[4]
	2-(2,4-dichlorophenoxy)-5-ethylphenol	Drug Info	IC50 = 110 nM	[4]
	2-(2,4-dichlorophenoxy)-5-isobutylphenol	Drug Info	IC50 = 180 nM	[6]
	2-(2,4-dichlorophenoxy)-5-isopentylphenol	Drug Info	IC50 = 120 nM	[6]
	2-(2,4-dichlorophenoxy)-5-methylphenol	Drug Info	IC50 = 200 nM	[4]
	2-(2,4-dichlorophenoxy)-5-phenethylphenol	Drug Info	IC50 = 76 nM	[6]
	2-(2,4-dichlorophenoxy)-5-propylphenol	Drug Info	IC50 = 210 nM	[4]
	2-(4-amino-2-chlorophenoxy)-5-chlorophenol	Drug Info	IC50 = 360 nM	[1]
	2-(4-chloro-2-hydroxyphenoxy)benzenaminium	Drug Info	IC50 = 7000 nM	[6]
	3,7,3',4'-TETRAHYDROXYFLAVONE	Drug Info	IC50 = 1000 nM	[2]
	3,7-dihydroxy-flavone	Drug Info	IC50 = 10000 nM	[2]
	3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide	Drug Info	IC50 = 120 nM	[1]
	4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol	Drug Info	IC50 = 440 nM	[4]
	4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol	Drug Info	IC50 = 38 nM	[4]
	4-(2,4-dichloro-phenoxy)-biphenyl-3-ol	Drug Info	IC50 = 140 nM	[4]
	4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol	Drug Info	IC50 = 230 nM	[6]
	4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile	Drug Info	IC50 = 49 nM	[4]
	4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol	Drug Info	IC50 = 190 nM	[6]
	5-benzyl-2-(2,4-dichlorophenoxy)phenol	Drug Info	IC50 = 71 nM	[6]
	5-butyl-2-(2,4-dichlorophenoxy)phenol	Drug Info	IC50 = 480 nM	[6]
	5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol	Drug Info	IC50 = 220 nM	[1]
	5-chloro-2-(2-chloro-4-nitrophenoxy)phenol	Drug Info	IC50 = 180 nM	[1]
	BUTEIN	Drug Info	Ki = 14 nM	[3]
	Epigallocatechin gallate	Drug Info	Ki = 8 nM	[3]
	GALLOCATECHIN GALLATE	Drug Info	IC50 = 500 nM	[2]
	ISORHAMNETIN	Drug Info	IC50 = 5000 nM	[2]
	MORIN	Drug Info	IC50 = 5000 nM	[2]
	OROIDIN	Drug Info	Ki = 800 nM	[5]
References
REF 1	Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52.
REF 2	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
REF 3	Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
REF 4	X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
REF 5	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tubercul... Bioorg Med Chem. 2007 Nov 1;15(21):6834-45.
REF 6	Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19.
REF 7	Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis. Curr Top Med Chem. 2007;7(5):489-98.

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