| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T53764 | ||||
| Target Name | Prolyl endopeptidase FAP (FAP) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Drug Info | IC50 = 4.6 nM | [1] | ||
| PF-00734200 | Drug Info | IC50 = 10300 nM | [2] | ||
| References | |||||
| REF 1 | Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4239-42. | ||||
| REF 2 | (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipepti... Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5. | ||||
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