| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T55922 | ||||
| Target Name | S-adenosylmethionine decarboxylase proenzyme (AMD1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | 5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine | Drug Info | IC50 = 600 nM | [1] | |
| 5'-Deoxy-5'-(N,N-dimethylamino)adenosine | Drug Info | IC50 = 9000 nM | [1] | ||
| 5'-Deoxy-5'-dimethylsulfonioadenosine chloride | Drug Info | IC50 = 5000 nM | [1] | ||
| [(2-aminooxyethyl)methylamino]-5'-deoxyadenosine | Drug Info | IC50 = 55 nM | [1] | ||
| References | |||||
| REF 1 | New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. | ||||
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