Target Validation Information
TTD ID	T56556
Target Name	ATP-binding cassette transporter G2 (ABCG2)
Type of Target	Successful
Action against Disease Model	Sulfasalazine	Drug Info	Sulfasalazine induces apoptosis both in Jurkat cells, a h uMan T??leukaemia cell line (ED50 value ???1.0 mM), and in primary h uMan peripheral blood T??lymphocytes (ED50 value ???0.5 mM). In contrast SW620 colon carcinoma cells or primary h uMan synoviocytes are not affected at these concentrations suggesting a cell type??specific sensitivity to sulfasalazine.	[1]
References
REF 1	Molecular mechanisms of sulfasalazine-induced T-cell apoptosis. Br J Pharmacol. 2002 Nov;137(5):608-20.

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