Target Validation Information
TTD ID	T58589
Target Name	B1 bradykinin receptor (BDKRB1)
Type of Target	Clinical trial
Drug Potency against Target	Des-Arg10-Kallidin	Drug Info	Ki < 0.2 nM	[2]
	Des-Arg10-Leu9-Kallidin	Drug Info	Ki < 0.2 nM	[2]
	H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1638)	Drug Info	Ki = 5.6 nM	[1]
	H-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1669)	Drug Info	Ki = 0.22 nM	[1]
	JMV1431	Drug Info	Ki = 83 nM	[1]
References
REF 1	Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6.
REF 2	Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8.

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