Target Validation Information
TTD ID	T59626
Target Name	Leukotriene B4 receptor 1 (LTB4R)
Type of Target	Clinical trial
Drug Potency against Target	LY293111	Drug Info	IC50 = 17 nM
	(3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol	Drug Info	IC50 = 7200 nM
	(LTB4-(Csa)4)2-Glu-H Conjugate	Drug Info	IC50 = 8 nM	[1]
	Biomed 101	Drug Info	IC50 = 1 nM
	CP-105696	Drug Info	IC50 = 5 nM
	DTPA Conjugate	Drug Info	IC50 = 30 nM	[1]
	HYNIC Analogue	Drug Info	IC50 = 44 nM	[1]
	Leucettamidine	Drug Info	Ki = 5300 nM
	LEUCETTAMINE A	Drug Info	IC50 = 4600 nM
	LTB4	Drug Info	IC50 = 32 nM
	LY-282210	Drug Info	IC50 = 47 nM	[2]
	LY-292728	Drug Info	IC50 = 1.2 nM	[2]
	SB-201146	Drug Info	Ki = 4.7 nM	[3]
	SB-201993	Drug Info	Ki = 7.1 nM	[3]
	SC-50073	Drug Info	IC50 = 0.85 nM
	SC-50135	Drug Info	IC50 < 0.1 nM
	SC-50676	Drug Info	IC50 = 5.3 nM
	SC-51146	Drug Info	IC50 = 10.9 nM
	SC-52073	Drug Info	IC50 = 0.1 nM
	SC-52569	Drug Info	IC50 = 0.15 nM
	SC-53228	Drug Info	IC50 = 14.5 nM
	SC-53229	Drug Info	IC50 = 8.5 nM
References
REF 1	Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. J Med Chem. 2005 Oct 6;48(20):6442-53.
REF 2	Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.
REF 3	(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist w... J Med Chem. 1996 Sep 13;39(19):3837-41.

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