| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T60688 | ||||
| Target Name | Survivin messenger RNA (Survivin mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Action against Disease Model | ISIS 23722 | Drug Info | For HeLa cell line: IC50=8+/-3 nM,n=5;For T24 cell line:IC50=29+/-10 nM,n=3;HCT116 cell line:IC50=64+/-18 nM,n=3;A549 cell line: IC50=49+/-16 nM,n=3;PC3 cell line: IC50=21+/-7 nM,n=3. | [1] | |
| References | |||||
| REF 1 | Integrated analysis of preclinical data to support the design of the first in man study of LY2181308, a second generation antisense oligonucleotide. Br J Clin Pharmacol. 2011 Mar;71(3):416-28. | ||||
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