Target Validation Information
TTD ID	T60857
Target Name	Dihydrodiol dehydrogenase type I (AKR1C3)
Type of Target	Successful
Drug Potency against Target	2-(4-chlorobenzylidene)cyclopentylmethyl ether	Drug Info	Ki = 16200 nM	[3]
	2-[(2,2-diphenylacetyl)amino]benzoic acid	Drug Info	IC50 = 11000 nM	[1]
	3-Bromo-5-phenylsalicylc acid	Drug Info	Ki = 4200 nM	[4]
	EM-1424	Drug Info	IC50 = 9.5 nM	[2]
	EM1396	Drug Info	IC50 = 13 nM	[2]
	M-Phenoxybenzoic Acid For Cis-Isomer	Drug Info	IC50 = 680 nM	[1]
References
REF 1	Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of ant... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5.
REF 2	Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J Biol Chem. 2007 Mar 16;282(11):8368-79.
REF 3	New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71.
REF 4	Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.