| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T65197 | ||||
| Target Name | Erythropoietin Receptor (EPOR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Darbepoetin alfa | Drug Info | EC50 = 0.703 nM | [1] | |
| Epoetin alfa | Drug Info | EC50 = 0.138 nM | [1] | ||
| Action against Disease Model | Darbepoetin alfa | Drug Info | Further, relative biologic activity, measured by determining in vitro proliferation effects of both agents on the UT7/EPO cell line, indicated that the effective ligand concentration to obtain 50% biologic activity (EC50) was 0.0589 nM for darbepoetin alfa | [2] | |
| Epoetin alfa | Drug Info | Further, relative biologic activity, measured by determining in vitro proliferation effects of both agents on the UT7/EPO cell line, indicated that the effective ligand concentration to obtain 50% biologic activity (EC50) was 0.0115 nM for epoetin alfa. | [1] | ||
| References | |||||
| REF 1 | The evolving role of epoetin alfa in cancer therapy. Oncologist. 2004;9(1):97-107. | ||||
| REF 2 | CERA (Continuous Erythropoietin Receptor Activator): a new erythropoiesis-stimulating agent for the treatment of anemia. Curr Hematol Rep. 2005 Nov;4(6):436-40. | ||||
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