| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T66505 | ||||
| Target Name | Smoothened homolog (SMO) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | 1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine | Drug Info | IC50 = 2246 nM | [2] | |
| CYCLOPAMINE | Drug Info | IC50 = 1200 nM | [1] | ||
| References | |||||
| REF 1 | Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signali... Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. | ||||
| REF 2 | 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem. 2009 Jul 9;52(13):3954-68. | ||||
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