Target Validation Information
TTD ID	T67710
Target Name	Parathyroid hormone 1 receptor (PTH1R)
Type of Target	Successful
Action against Disease Model	Teriparatide	Drug Info	Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A h uMan PTH fragment, PTH [1-34], stimulated adenylate cyclase with the EC50 value of 3 nM, but not phospholipaseC. PTH [1-34] changed the morphology of protoplasmic type astrocytes into process-bearing ones. Thus, type I astrocytes possess PTH/PTHrP receptor that is coupled to an adenylate cyclase-activating system but not to phospholipase C.	[1]
References
REF 1	Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes. Biochem Biophys Res Commun. 1994 Apr 29;200(2):1042-8.

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