| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T68782 | ||||
| Target Name | Prostaglandin D2 receptor (PTGDR) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Laropiprant+niacin | Drug Info | IC50 = 0.9~4 nM | [2] | |
| DIASTEREOMER 2 | Drug Info | Ki = 8.9 nM | [1] | ||
| LAROPIPRANT | Drug Info | IC50 = 4 nM | [1] | ||
| References | |||||
| REF 1 | Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. | ||||
| REF 2 | Targeting ischemic stroke with a novel opener of ATP-sensitive potassium channels in the brain. Mol Pharmacol. 2004 Nov;66(5):1160-8. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.