Target Validation Information
TTD ID	T69085
Target Name	Transcription factor AP-1 (JUN)
Type of Target	Discontinued
Drug Potency against Target	TWS-119	Drug Info	IC50 = 15000 nM	[1]
Action against Disease Model	T-5224	Drug Info	The in vivo ED50 of T-5224 corresponds to a Cmax of 0.03-0.5 uM, a figure that is substantially lower than the in vitro IC50 of ~10 uM.	[2]
References
REF 1	Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84.
REF 2	Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008 Jul;26(7):817-23.

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