| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T70310 | ||||
| Target Name | Bacterial DNA ligase (Bact ligA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | 2,3-dioxoindoline-7-carboxylic acid | Drug Info | IC50 = 4000 nM | [1] | |
| 3-amino-2-(benzylideneamino)-5-mercaptophenol | Drug Info | IC50 = 4000 nM | [1] | ||
| 5-(methylthio)thiophene-2-carboxylic acid | Drug Info | IC50 = 10000 nM | [1] | ||
| References | |||||
| REF 1 | Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. | ||||
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