Target Validation Information
TTD ID	T71390
Target Name	Steroid 5-alpha-reductase 2 (SRD5A2)
Type of Target	Successful
Drug Potency against Target	2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol	Drug Info	IC50 = 2000 nM	[3]
	3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid	Drug Info	IC50 = 2800 nM	[2]
	4,4'-dihydroxyoctafluoroazobenzene	Drug Info	IC50 = 790 nM	[3]
	4-(4-phenoxybenzoyl)benzoic acid	Drug Info	IC50 = 53 nM	[2]
	4-[4-benzyloxy)benzoyl]benzoic acid	Drug Info	IC50 = 119 nM	[2]
	FK-143	Drug Info	IC50 = 4.2 nM	[1]
	ONO-3805	Drug Info	IC50 = 2.6 nM	[1]
References
REF 1	Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpipera... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1553-8.
REF 2	Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59.
REF 3	Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5.

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