Target Validation Information
TTD ID	T72335
Target Name	Bacterial Lethal factor (Bact lef)
Type of Target	Clinical trial
Drug Potency against Target		Drug Info	IC50 = 2300 nM	[4]
	3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid	Drug Info	IC50 = 15000 nM	[3]
	Bisindolylmaleimide-I	Drug Info	IC50 = 1500 nM	[4]
	GNF-PF-600	Drug Info	IC50 = 3000 nM	[2]
	MMI270	Drug Info	IC50 = 12000 nM	[1]
	N-(3,4,5-trihydroxyphenethyl)oleamide	Drug Info	Ki = 1700 nM	[5]
	N-(3,4-dihydroxybenzyl)oleamide	Drug Info	IC50 = 15000 nM	[6]
	N-hydroxy-4-(2-oleamidoethyl)benzamide	Drug Info	Ki = 6000 nM	[5]
	N-hydroxy-4-(oleamidomethyl)benzamide	Drug Info	Ki = 6200 nM	[6]
	N-oleoyl-dopamine	Drug Info	Ki = 3000 nM	[5]
	NSC-622445	Drug Info	Ki = 4900 nM	[3]
References
REF 1	The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8.
REF 2	Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. J Med Chem. 2006 Jan 12;49(1):27-30.
REF 3	Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44.
REF 4	Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11.
REF 5	Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8.
REF 6	Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70.

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