Target Validation Information
TTD ID	T75797
Target Name	Prostaglandin F2-alpha receptor (PTGFR)
Type of Target	Successful
Drug Potency against Target	Latanoprost	Drug Info	Ki = 98 nM	[3]
	Travoprost	Drug Info	EC50 = 17.5~37 nM	[2]
	LAROPIPRANT	Drug Info	Ki = 9991 nM	[1]
References
REF 1	Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806.
REF 2	Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors. J Pharmacol Exp Ther. 2003 Jan;304(1):238-45.
REF 3	Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15.

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