Target Validation Information
TTD ID	T76059
Target Name	FK506-binding protein 1A (FKBP1A)
Type of Target	Successful
Drug Potency against Target	GPI-1485	Drug Info	IC50 = 5 nM	[1]
Action against Disease Model	GPI-1485	Drug Info	Oral dosing in animals with GPI 1485 stimulates significant neuroprotective and neuroregenerative activity in preclinical models of post-prostatectom erectile dysfunction. Treatment with GPI 1485 at the time of injury maintained intracavernosal pressure at near normal levels for up to 28 days after injury. In addition, delayed treatment with GPI 1485 up to seven days after the peripheral nerve injury procedure promoted significant restoration of function, restoring intracavernosal pressure to between 90%-100% of normal levels when measured at one month after injury.
References
REF 1	Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8.

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