Target Validation Information
TTD ID T77400
Target Name Phosphodiesterase 2A (PDE2A)
Type of Target
Clinical trial
Drug Potency against Target (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol Drug Info Ki = 1000 nM [2]
2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one Drug Info IC50 = 6000 nM [1]
BAY-60-7550 Drug Info IC50 = 4.7 nM [2]
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine Drug Info IC50 = 19000 nM [4]
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine Drug Info IC50 = 17000 nM [4]
isobutylmethylxanthine Drug Info IC50 = 12000 nM [3]
References
REF 1 PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.
REF 2 The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62.
REF 3 A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45.
REF 4 Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.