| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T78111 | ||||
| Target Name | Nicotinic acetylcholine receptor (nAChR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Nicotine | Drug Info | Ki = 19.4 nM | [2] | |
| Dianicline | Drug Info | Ki = 42900 nM | [3] | ||
| PROTOSTEMODIOL | Drug Info | IC50 = 10000 nM | [1] | ||
| References | |||||
| REF 1 | Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. J Nat Prod. 2008 Jan;71(1):112-6. | ||||
| REF 2 | Receptor binding thermodynamics at the neuronal nicotinic receptor. Curr Top Med Chem. 2004;4(3):361-8. | ||||
| REF 3 | Low molecular weight inhibitors of the protease anthrax lethal factor. Mini Rev Med Chem. 2008 Mar;8(3):290-306. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.