| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T81900 | ||||
| Target Name | Insulin-degrading enzyme (IDE) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Bacitracin | Drug Info | IC50 = 400000 nM | [2] | |
| GNF-PF-4478 | Drug Info | IC50 = 10854 nM | [1] | ||
| References | |||||
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | ||||
| REF 2 | Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.