Target Validation Information
TTD ID T86052
Target Name Telomerase reverse transcriptase (TERT)
Type of Target
Clinical trial
Drug Potency against Target GRN163 Drug Info IC50 = 0.1 nM [1]
Action against Disease Model Imetelstat Drug Info GRN163 has been shown to inhibit telomerase activity in 19 t uMor cell lines, with an average IC50 of 0.5-1.0 uM. [2]
REF 1 Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 2005 Aug 4;24(33):5262-8.
REF 2 Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology. 2005 Nov;42(5):1127-36.

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